Colloidal silicon dioxide Anhydrous is a highly pure, very fine amorphous silicon dioxide having primary particles in the nano-scale range. As these adsorption-desorption processes can potentially influence functionality, colloidal silicon dioxide should be stored away from conditions likely to expose it to these types of contamination. Provided it is stored appropriately and as recommended, the material does not undergo any significant chemical changes, even after several decades. Mol Phys 107:831843. (2016) Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. [7] D. Majerov, L. Kulaviak, M. Rika, F. tpnek, P. Zmostn, Effect of colloidal silica on rheological properties of common pharmaceutical excipients, European Journal of Pharmaceutics and Biopharmaceutics, 106 (2016) 2-8. Surf Sci Rep 69:132158. https://doi.org/10.1021/acsami.9b15396, Dong Z, Mao J, Yang M et al. When the system is mechanically sheared, such as through shaking, the structure is broken down, rendering the system more fluid as the viscosity drops. These dispersions are stable below a pH of 4. Nanoscale 7:1504615050. Practically insoluble in water, propylene glycol, glycerol, organic solvents, mineral oil, and most acids. 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(2020) Targeted manganese doped silica nano GSH-cleaner for treatment of liver cancer by destroying the intracellular redox homeostasis. https://doi.org/10.1021/acs.chemmater.8b04647, Perdoor SS, Dubois F, Barbara A et al. https://doi.org/10.1021/cm0112441, Chen JF, Ding HM, Wang JX, Shao L (2004) Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. Suspensions of fine amorphous silica particles in a liquid, Learn how and when to remove this template message, It increase the bulk & taped density of powder & granules also, It is also be used in Lubrication of Tablet, https://en.wikipedia.org/w/index.php?title=Colloidal_silica&oldid=1136551695, Articles lacking sources from November 2021, Creative Commons Attribution-ShareAlike License 3.0, Stabilizing and rigidizing refractory ceramic fiber blankets, Liquid silicon dioxide (colloidal silica) is used as a wine and juice, This page was last edited on 30 January 2023, at 22:28. J Am Chem Soc 133:25252534. (2016) Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids. It is recommended to use rotor-stator or dissolver homogenisers having a tip speed of 15 m/sec or more. J Colloid Interface Sci 410:8193. The obtained powdered formulations can be easily compressed into tablets on standard presses. Silica rich foods include whole grains especially oatmeal and brown rice and root vegetables. Synthetic Amorphous Silica (SAS) exhibits a randomized internal structure (amorphous), and is distinct from natural or other synthetic crystalline silica types. Aggregation affects the diffusion, gravitational settling, and the available NPs' surface. It can be found in nature in crystalline form (as quartz sand), and it is the most abundant component of the earth's crust. (2016) Functionalized silica nanoparticles as an alternative platform for targeted drug-delivery of water insoluble drugs. Naturally occurring in Quartz crystal, colloidal mineral silica (importantly, the element silicon contained within it) is the second most abundant element in the Earth's crust. The long history of manufacture and use, coupled with data regarding the size distribution of the material, substantiates the widespread belief that colloidal silicon dioxide has a low potential for adverse health effects. This is the reason micronised powders do not flow well. [4] M. Fuji, H. Iwata, T. Takei, T. Watanabe, M. Chikazawa, The change in the water vapor affinity of fine silica particles loaded with trimethylsilyl groups, Advanced Powder Technology, 8 (1997) 325-334. Adv Colloid Interface Sci 123126:515. Crystalline forms of Silica exhibit a highly ordered crystal lattice, determined by the ordered arrangement of the Silica tetrahedra. Chemistry 22:1480614811. Free silica (Silicon dioxide) is a hard, low-reactivity, colourless substance that occurs naturally in rocks and minerals or can also be industrially produced in the form of synthetic amorphous silica. Prog Polym Sci 17:163249. (2019) Corona composition can affect the mechanisms cells use to internalize nanoparticles. Chem Rev 65:177198. Liquid should not be frozen. ACS Appl Mater Interfaces 8:2280822818. A summary of relevant toxicological data for Colloidal silicon dioxide is provided in the table below: The European Unions Scientific Committee on Food (SCF) and the Joint FAO/WHO Expert Committee on Food Additives assessed the safety of different silica products and established a group acceptable daily intake (ADI) for silicon dioxide as not specified. What is important is tip speed. J Phys Chem 66:967973. https://doi.org/10.1021/ja00053a020, Kresge CT, Leonowicz ME, Roth WJ et al. Sodium silicates are alkaline solutions with pH ranges of 12-13, compared to 9-11 for colloidal silica. The following regulatory schedules apply to colloidal silicon dioxide: Several grades of colloidal silicon dioxide are widely available, depending mainly on the method of production, and any subsequent processing changes that the material is subjected to. Theranostics 5:631642. https://doi.org/10.1021/acs.langmuir.0c01571, Braun K, Pochert A, Beck M et al. In addition, the hydrophilic nature of Colloidal silicon dioxide enables it to attract and preferentially bind moisture, helping to eliminate liquid bridges between solid particles that hinder powder flow. https://doi.org/10.1016/0021-9797(70)90234-1. CHARACTERS (2021) Tailored mesoporous inorganic biomaterials: assembly, functionalization, and drug delivery engineering. For a long time, Colloidal silicon dioxide was incorrectly associated with crystalline forms of silica since the two materials shared the same name and chemical formula. Description Description AEROSIL 200 Pharma AEROSIL 200 Pharma is a high purity amorphous anhydrous colloidal silicon dioxide for use in pharmaceutical products. Qsilica ONE-A-DAY tablets are oval shaped and approximately 22mm long by 10mm wide. Particle sizes range from about 1 to 100 nm. As a result, MADG offers multiple advantages, including reduced energy costs, fewer processing steps, and reduced investment in machinery. The authors declare no competing interests. https://doi.org/10.1016/j.micromeso.2019.04.050, Allen LH, Matijevi E (1970) Stability of colloidal silica II. https://doi.org/10.7150/thno.46771, Maggini L, Travaglini L, Cabrera I et al. All information is provided in good faith to enable collaboration and sharing of know-how among our community of users. https://doi.org/10.1002/chem.201601714, Fei W, Chen D, Tang H et al. Anal Chem 78:646654. According to the definition of ISO TS 80004-1, Colloidal silicon dioxide (and other synthetic amorphous silicas) are nanostructured. ACS Nano 12:49304937. https://doi.org/10.1021/acsami.6b09950, Gollwitzer C, Bartczak D, Goenaga-Infante H et al. Colloidal silicas are suspensions of fine amorphous, nonporous, and typically spherical silica particles in a liquid phase. They may also be present in a narrow or wide particle size range, depending on the process in which they were created. In this sense, fumed silica particles are dispersed in a gaseous phase during production process. Properties Free flow and anti-caking agent to improve powder properties Improves tablet properties such as hardness and friability Blood 55:156159. Angew Chem Int Ed 55:33233327. Colloids Surf B Biointerfaces 186:110677. https://doi.org/10.1016/j.colsurfb.2019.110677, Monopoli MP, Walczyk D, Campbell A et al. In standard coating processes involving powder layering, Colloidal silicon dioxide is used to facilitate powder build-up in the coating while also helping maintain pigments in suspension. 7631-86-9. Nanomaterials 7:162. https://doi.org/10.3390/nano7070162, Lin Y, Abadeer N, Hurley KR, Haynes CL (2011) Ultrastable, redispersible, small, and highly organomodified mesoporous silica nanotherapeutics. Carrier for solid dispersions. Usually they are suspended in an aqueous phase that is stabilized electrostatically. The smaller the particles, the greater the interactions, and thus, the more cohesive a powder is. https://doi.org/10.1007/978-3-642-72624-8_11, Kontogeorgis GM, Kiil S (2016) Introduction to applied colloid and surface chemistry. (1990) Reduced thrombogenicity of polymers having phospholipid polar groups. Colloidal silica varies from other types of silica in several significant ways. There are many grades of colloidal silica, but all of them are composed of silica particles ranging in size from about 2 nm up to about 150 nm. Aerosil Colloidal Silicon Dioxide for Pharmaceuticals Technical Information Bulletin, SIPERNAT and AEROSIL an essential in industrial powder technology Evonik Industries Technical Information 1360, Aerosil and Sipernat Silica as Thickeners for Personal Care. (2020) Selective targeting of lymphoma cells by monoclonal antibody grafted onto Zwitterionic-functionalized nanoparticles. We look forward to hearing from you. https://doi.org/10.1016/j.cis.2006.05.001, Tadros T (2011) General principles of colloid stability and the role of surface forces. Silicon and oxygen are the two most abundant elements in the earths crust. [10] R.D.A. Microporous Mesoporous Mater 314:110886. https://doi.org/10.1016/j.micromeso.2021.110886, Carvalho GC, Sbio RM, de Cssia Ribeiro T, et al. Colloidal silicon dioxide improves powder flow by counteracting the forces behind particle cohesion. Cambridge University Press, Bergstrm L (1997) Hamaker constants of inorganic materials. Note that these silica grades can be used in their native (unprocessed) state. Parteck SLC excipient is an innovative silica drug carrier that enhances drug solubility thanks to its unique surface structure, which can stabilize the amorphous state. Therefore, the mean diameter of the resulting synthetic amorphous silica particles, as used, is typically in the micron range and well above 100 nm. The recommended usage levels are generally between 0.5 to 3.0% w/w. Proc Natl Acad Sci USA 115:28902895. This random distribution is what makes amorphous silica different from crystalline silica - ordered on a molecular level. Lipid formulations: Solutions of API in suitable oil carriers can be absorbed by the mesoporous silica, which can then be converted into free-flowing powders. This versatility stems from its high absorptive capacity, ability to improve flow, and low dust content, as outlined in the table below: When applied to pharmaceutical products, the above-listed Silica attributes provide the following functionalities: Thus, Colloidal silicon dioxide functions, in both solid and liquid dosage forms, as a: In tablets, capsules, and granules, Colloidal silicon dioxide is popularly used as a glidant and anti-adherent, where it allows powder formulations to efficiently flow on high-speed tablet presses. https://doi.org/10.1021/ja951550d, West R, Whatley LS, Lake KJ (1961) Hydrogen bonding studies. Language links are at the top of the page across from the title. V. The relative basicities of ethers, alkoxysilanes and siloxanes and the nature of the silicon-oxygen bond. Precipitated silica, on the other hand, is mesoporous and exhibits an internal surface. If more serious issues such as unusual hair loss or skin problems are the primary concerns, it is suggested that professional health care advice is sought - factors such as stress or hormonal imbalance may need to be considered. Nat Nanotechnol 8:772781. Where possible, colloidal silicon dioxide should be used within 6 to 12 months of the production date. J Phys Chem C 119:2735427362. https://doi.org/10.1039/d0nr06040b, Capeletti LB, Oliveira JFA, Loiola LMD et al. https://doi.org/10.1039/C3MH00106G, Nel AE, Mdler L, Velegol D et al. The added organic groups are tightly bound to the surface (via covalent bonds) and are only broken via thermal decomposition. https://doi.org/10.1021/acs.chemmater.9b00221, Choi E, Lim D-K, Kim S (2020) Hydrolytic surface erosion of mesoporous silica nanoparticles for efficient intracellular delivery of cytochrome c. J Colloid Interface Sci 560:416425. (2015) Bimodal acidity at the amorphous silica/water interface. Adv Health Mater 7:1700831. https://doi.org/10.1002/adhm.201700831, Maggini L, Cabrera I, Ruiz-Carretero A et al. J Inorg Nucl Chem 33:12931299. Chem Mater 28:90089016. HWQs~LN :9'$}%bu*. EUROPEAN PHARMACOPOEIA 6.0 Silica, colloidal hydrated 01/2008:0434 corrected 6.0 SILICA, COLLOIDAL ANHYDROUS Silica colloidalis anhydrica SiO2 Mr 60.1 [7631-86-9] DEFINITION Colloidal anhydrous silica contains not less than 99.0 per cent and not more than the equivalent of 100.5 per cent of SiO2, determined on the ignited substance.